PD(ICD)+ patients as well as drug-naïve PD patients have been shown through DTI tractography to have widespread white matter tract damage in particular showing increased radial and axial diffusivity of the genu of corpus callosum and the pedunculopontine tract [39, 41, 42]. In another report using tract-based spatial statistics PD(ICD)+ patients showed increased fractional anisotropy in several white matter tracts that also included the anterior corpus callosum. However, white matter in regions known to be involved in reward- related behaviours were preserved [43]. Taken together, it seems that white matter connectivity may be indeed an impor- tant parameter to consider in designing future studies in PD- related ICD.