Sparks and coworkers first used the term “descemetopexy” in 1967 to describe the surgical reattachment of detached DM with injection of air into the anterior chamber in three cases of post cataract surgery DMD. Since then, descemetopexy has become the gold standard treatment for the management of DMD. The rapid absorption of 100% air from the anterior chamber led to the concept of using isoexpansile gases,--2-14% per-fluoropropane (C3F8) and 14-20% sulphur hexafloride (SF6)--that would stay in the anterior chamber for longer time (14% C3F8- 6 weeks; 20% SF6- 2 weeks).Isoexpansile gas reduces the need for repeat injections. The surgical technique involves filling the syringe with the desired gas, which is aspirated through a micropore filter. An anterior-chamber paracentesis is then made with a micro vitreoretinal blade or the gas is injected with a 26 or 30-gauge needle. The site of entry chosen should be opposite to or away from the area of the DMD where the DM is attached. Once adequate aqueous is ejected, a continuous, single bubble of the gas is injected into the anterior chamber directing towards the maximum height of DMD.