In the daily nursing work to actively talk with patients, early detection of patients' mood, behavior, personality and other abnormalities. The early symptoms of hepatic encephalopathy were hidden and hidden, and the nursing staff strengthened the observation on the patients. At the same time, combining with the changes of biochemical indicators of the patients, it was determined whether the patients had hepatic encephalopathy. Report to the doctor in time, take safety measures, open the bed block, use the restraint belt when necessary, prevent the patient from falling off the bed, pull out the puncture needle, drainage tube, etc., causing body damage. And guide the families of patients to find the abnormal changes of patients as early as possible, early detection of hepatic encephalopathy, for early intervention.