In an oral ingestion scenario, in v

In an oral ingestion scenario, in vitro gastrointestinal methods were applied to estimate the bioaccessibility of heavy metals, " persistent organic pollutants (POPs) . and various food sources and soils. The bioaccessibility of a chemical or nutrient compound can be affected by mole- cular interactions between the potential physicochemical con ditions and the food matrix. here are dietary fibers which might be added deliberately for their flavor or health aspects. The influence of digestive conditions, such as gastro intestinal pH, time, and the solid-liquid (/ L) ratio, on the bioaccessibility of certain contaminants has been reported, including pesticides. Our previous investigation on the release of pesticides during simulated digestion using a static model showed a significant effect of the physicochemical conditions. It was deduced that the presence of food may influence the release of pesticides from the food matrix. However, so far, we have limited knowledge about how vari. ations in this parameter affect the bioaccessibility of pesticides during human digestion.