The procedure for assessing dementi

The procedure for assessing dementia status has been described in detail elsewhere [29]. In short, data to assess dementia status and disease onset was primarily drawn from clinical information in med- ical records, supplemented by outcomes from the Betula health- and cognitive testing. The diagnostic protocol did not systematically include cerebrospinal fluid or neuroimaging biomarkers nor postmortem neuropathological findings, but such information was part of the diagnostic decision when available. The information was sufficient for applying clinical criteria-based systems, such as the DSM-IV classifi- cation core criteria for dementia [36]. The diagnostic evaluation was performed by the same geropsychia- trist (co-author RA) throughout the study.