This can be promoted by mobilizing

This can be promoted by mobilizing any accumulated fluid through implementing diuretic or ultrafiltration therapies when necessary. This approach, though not yet validated in sepsis, provides a rational framework that considers the risk/benefit of fluid administration.ConclusionThe administration of IV fluid remains a crucial step in early resuscitation efforts of patients with sepsis or septic shock.However, multiple studies have demonstrated that repeated fluid administration and positive fluid balance throughout patients’ hospital stay is associated with an increase in mortality. These studies are limited by variations in their methodologic design. Future multicenter, randomized, controlled studies that evaluate fluid balance and fluid volume need to be conducted to clarify the role of fluid administration to patients with sepsis to maximize benefits and minimize risk.