R2 Parameter The R2 parameter for the active formulation increased in weeks 1 and 2, after which a sustained effect was observed throughout the study period (8 weeks), while no such remarkable changes were observed with the base (Fig. 3). When R2 parameter was subjected to ANOVA, insignificant results appeared for base and active formulation over time. When the paired t-test was applied to observe differences between base and active formulation, only a positive significant relation was found in week 1 of the study.