The dissolution is the predominant factor at an early stage, which may explain why the average size is higher in HS.At following stages(dwell times of 20 min or higher), the presence of a higher amount of solvent during the process due to the closed nature of the system leads to a lower kinetics to reach supersaturation and precipitation. In the meantime, during CSP, supersaturation considerably increases following evaporation, which may lead to larger grain sizes.