On the basis of available data from

On the basis of available data from randomized controlled trials, silicone gel or sheeting is the preferredfirst-line therapy for the treatment of linear hypertrophic scars. In cases where a 2-month course of siliconegel or sheeting does not prove effective or when thescar is severe, pruritic, or both, adjunctive use ofintralesional corticosteroid injection or 5-fluorouracil(5-FU) is indicated. Clinicians should be aware ofcontraindications to the use of 5-FU, including anemia, leukopenia, thrombocytopenia, pregnancy, bonemarrow depression, and infection. Side effects of 5-FUare generally localized and include pain at the injectionsite, hyperpigmentation, skin irritation, andulceration.