以上结果表明，长期拮抗OX1R会导致3xTg-AD小鼠多种不同类型的认

These results suggest that long-term OX1R antagonism can further aggravate various types of cognitive impairment in 3xTg-AD mice. At the same time, SB-334867 pretreatment did not affect the total number of arm advances in the Y-maze spontaneous alternation experiment, the swimming speed in the Morris water maze experiment, and the time to reach the visual platform in 3xTg-AD mice, indicating that SB-334867 pretreatment The treatment did not affect the visual acuity and motor ability of 3xTg-AD mice, further confirming that the poorer performance of 3xTg-AD mice in various behavioral experiments after SB-334867 pretreatment was due to further impairment of their cognitive function.

The above results show that long-term antagonism of ox1r will further aggravate many different types of cognitive impairment in 3xTG AD mice. At the same time, SB-334867 pretreatment did not affect the total arm entry times of 3xTG AD mice in the Y-maze spontaneous alternation experiment, the swimming speed in the Morris water maze experiment and the time to reach the visual platform, indicating that SB-334867 pretreatment did not affect the vision and motor ability of 3xTG AD mice, which further confirmed that the poor performance of 3xTG AD mice in various behavioral experiments after SB-334867 pretreatment was due to the further impairment of their cognitive function.

These results indicate that long-term antagonism of OX1R will further aggravate the cognitive impairment of 3xTg-AD mice. At the same time, the pretreatment of SB-334867 did not affect the total arm feeding times of 3xTg-AD mice in Y maze spontaneous alternation experiment, the swimming speed in Morris water maze experiment and the time to reach the visual platform, which indicated that the pretreatment of SB-334867 did not affect the eyesight and exercise ability of 3xTg-AD mice, which further confirmed that the poor performance of 3xTg-AD mice in various behavioral experiments after SB-34867 pretreatment was due to their cognition.