The pathogenesis of Coats disease is still unclear, but some studies have reported that VEGF is involved in this process. VEGF is a natural protein, which can cause vascular permeability increase, endothelial cell migration and proliferation. A large number of studies have found that the level of VEGF in Coats disease is increased, which indicates its role in the pathogenesis of Coats disease. It is inferred that the increase of VEGF level causes the increase of vascular permeability and the formation of peripheral capillaries<br>
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