As a result, when we coencapsu-lated the MCF-7 spheroid with a perforated and endothelializedPDMS tube in close proximity together in the ECM-like matrix,we observed outward migration of the GFP-HUVECs fromthe PDMS tube through the pore nearby the spheroid, gradu-ally reaching the body of the spheroid after 5–7 d (Figure 6G)