Incorporation of TiO2 particles in the formulation can enhance protein absorption andsubsequent osteoblast adhesion as observed in the current study. It is in great accordancewith the results obtained from TiO2-coated PLGA films used to promote the attachment andproliferation of human dermal fibroblasts and rat cortical neural cells [63]. Furthermore, thepresence of TiO2 particles enhances the hydrophilicity of composite scaffolds which plays apivotal role in attachment of HOB cells on PLGA/TiO2 scaffolds [64].