[Abstract] Objective To investigate and optimize the efficacy of intense pulsed light in the treatment of blepharitis-related keratoconjunctival diseases. Methods Eighty-four patients with blepharitis-related keratoconjunctival disease were randomly divided into observation group and control group, each with 42 cases. The control group was given 0.1% fluorometholone eye drops and 0.3% sodium hyaluronate eye drops 4 times a day. After cleaning the eyelid margin every morning and evening, apply tobramycin and dexamethasone ointment; the observation group optimized the intense pulsed light treatment based on the treatment of the control group. The subjective symptoms, morphology of eyelid margin, secretory state of meibomian glands, range and characteristics of keratoconjunctival lesions, and demodex counts were assessed in the two groups of patients before treatment and 2wk, 4wk and 8wk after treatment. Results Before treatment, there were no differences in subjective symptoms, eyelid morphology, meibomian gland secretion status, severity of keratoconjunctival lesions, and the number of Demodex among the two groups of patients (P>0.05). After treatment, the clinical observation indexes of the observation group at each time point were better than those of the control group (P
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