At 4 weeks, the expressions of inflammatory factors IL-1β and TNF-α secreted by M1 macrophages in Coaxial-0.1GO group and Coaxial-0.5GO group were significantly decreased, and the expressions of surface proteins CD163 and CD206 in M2 macrophages were significantly increased. High, suggesting that the sustained release of ASTA can maintain a good anti-inflammatory effect.
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