There is less evidence to support other methods of virtual CEsuch as i-Scan digital contrast and flexible spectral imaging color enhancement (FICE). There are currently insufficient data torecommend routine clinical use of these techniques, eventhough in theory and after proper training they could havesimilar applications [47, 59]. A few prospective studies suggested that blue laser imaging may achieve similar results to NBI[60 – 62]. Other emerging technologies, such as confocal endomicroscopy, endocytoscopy, Raman spectroscopy, and polarimetry, may have a future role but at this stage cannot be recommended for routine clinical use [59].