esulting in decreased FoXO1-dependent gene expression and adiposity.90 The beneficial effect of FCoR on insulin sensitivity and adiposity is helpful for exploring therapeutic targets for the prevention of human obesity and type 2 diabetes.Accumulating evidence demonstrate that acetylation participates in the regulation of FoXO1 function. Further research could explore how different acetyltransferases function on the same lysine residues, how the different modifications interact, and the functional roles of some acetylated lysines, such as the Lys597 in the FoXO1 TAD, newly identified through mass spectrometry.