Even superficial irritation can have a profound effect on skin. This is because of the “inflammation cascade,” an ever-worsening cycle where the initial irritation triggers skin’s natural response, leading to an intensified response, and triggering further irritation. Repeated or chronic exposure to inflammatory triggers may be more harmful over a lifetime than a one-time acute exposure. For example, repeated exposure to low-level environmental pollution and UV rays can lead to significant lifetime visible damage.