穗花杉双黄酮可以通过调节PI3K/Akt信号通路及炎性因子表达Hep

Amentotaxus Biflavones Akt signal pathway can Inflammatory Cytokines and Hep G2 cells by adjusting the IR PI3K /. After treatment Biflavones Amentotaxus GSK-3 and IL-6, IL-8, TNF-α, CRP lowering activity of PI3K, Akt, and p-Akt expression increased []. Wang Chaodeng oxymatrine was found possible to reduce fat induced by ApoE - / - mice in vivo lipid and insulin levels, and enhancing insulin receptor p-PI3K / PI3K, p-Akt insulin sensitivity index and the liver / Akt protein GLUT2 and improve dyslipidemia and IR []. Studies have shown that [], sericin has excellent hypoglycemic effect and improve IR, to enhance their diabetic rat liver, pancreas IRS-1, PI3K, Akt protein and mRNA expression.

Spike flavonoids can be expressed by regulating pi3K/Akt signaling pathways and inflammatory factors in THE EXPRESSION of IR in Hep G2 cells. After treatment with sequoia biflavonoids, GSK-3 and IL-6, IL-8, TNF-alpha, CRP activity decreased and PI3K, Akt and p-Akt protein expression increased. Wang Chao et al. found that oxidizing bitter lychosine can reduce the level of glycolipids and insulin levels in high-fat-induced ApoE-/-mouse, enhance insulin sensitivity index and insulin receptors in liver tissue and protein expression of p-PI3K/PI3K, p-Akt/Akt and GLUT2, improve blood lipid disorders and IR. Studies have shown that silk gum has good blood sugar lowering and improved IR effects, which are associated with the enhancement of liver, pancreatic IRS-1, PI3K, Akt protein and mRNA expression in diabetic rats.

It can express IR in HepG2 cells by regulating PI3K / Akt signaling pathway and inflammatory factors. The activity of GSK-3, IL-6, IL-8, TNF - α and CRP decreased, while the expression of PI3K, Akt and p-Akt protein increased [. Wang Chao et al. Found that Oxymatrine can reduce the level of glycolipid and insulin in ApoE - / - mice induced by high fat, enhance the expression of insulin sensitivity index, insulin receptor, p-pi3k / PI3K, p-Akt / Akt and GLUT2 protein in liver tissue, improve the disorder of blood lipid and IR []. The results showed that [], sericin has a good effect on lowering blood sugar and improving IR, which is related to the enhancement of IRS-1, PI3K, Akt protein and mRNA expression in the liver and pancreas of diabetic rats.