ResultsGPX4 inhibition selectively attenuates the cGAS–STING pathway. Inactivation of GPX4 results in overwhelming lipid peroxidation and may cause ferroptosis. We first examined the effect of GPX4 inactivation on cell viability using RSL3 and FIN56, two selective GPX4 inhibitors. RSL3 is a covalent inhibitor of GPX4