Coronary artery disease remains the first cause of mortality worldwide [1]. Coronary artery disease contributes to the major cause of cardiovascular mortality, being responsible for approximately seven million of deaths [2]. Among all types of coronary artery diseases, acute coronary syndrome (ACS) is the most serious one. Each year in America, there are approximately 635,000 new diagnosed ACS patients [3– 8]. It is also associated with longer hospitalization and more frequent revisits [9, 10].