Empiric coverage for human bites should cover mixed flora, with special attention to E. cOlTodens, because it is not susceptible to Outpatient management with oral amoxicillin/clavulanate is first line for a1l mammalian bites, with TMP/SMX or an extended-spectrum cephalosporin(e.g., cefuroxime) in combination with clindamycin as alternatives in patients with penicillin allergies