Here, we propose an efficient evolutionary process for designing novel (R)-ω-TAs for the asymmetric amination of prochiral ketones to synthesize sitagliptin intermediates.
This article proposes a design novel (R)- ω- The effective evolutionary process of TA used in the asymmetric amination of prochirality ketones to synthesize sitagliptin intermediates.
In this paper, an effective evolution process of designing a novel (R)-ω-TA for asymmetric amination of prochiral ketones to synthesize sitagliptin intermediates is proposed.