Pulmonary fibrosis (PF) is an irreversible disease characterized by parenchymal progressive cicatricial lesions of the lung and loss of lung function, with a high mortality rate and no specific drugs.The pathological process of pulmonary fibrosis is characterized by the proliferation and differentiation of Human embryonic lung fibroblast cells(HEL) into myofibroblasts (MF) under stimulation, accompanied by excessive deposition of extracellular matrix(ECM) and abnormal remodeling of lung tissues. Therefore, inhibiting the proliferation and transformation of HEL cells is an important way to prevent and treat PF.