In the termination phase, the liver

In the termination phase, the liver tissue begins to stop proliferating after it has grown to a certain size. Current studies have shown that growth inhibitors such as TGF and Activin a exert a negative regulatory effect when the liver is restored to its original quality, resulting in a certain number of liver cells and restoration of liver quality, to Stop the regeneration process. After the liver regains its original size, TGF-inhibits the growth of hepatocytes to maintain a constant liver mass. The reason that TGF-can block the signal transduction of growth factor may be that it can regulate the expression of Cyclin d 1 And e, and then inhibit the synthesis of DNA. It has been found that TGF can inactivate Cyclin e/cdk2 complex, decrease the transcriptional activity of CDK2 and CDK4, and then inhibit hepatocyte proliferation. Recent studies have shown that the activation of P53/mir-34a/SIRT1 positive feedback arc pathway can promote the downstream apoptotic proteins and inhibit the expression of proliferating proteins, thus leading to the early termination of liver regeneration.