Systematic second-look surgery with

Systematic second-look surgery with HIPEC for CRC patients who are at highrisk for developing PM has aroused a growing interest among the scientificcommunity. The concept was first used by Wangensteen in 1948. The principles are based on the use of planned relaparotomy in asymptomatic patients with malignant disease who considered to be at risk for developing recurrent or metastatic disease despite (i) initial curative surgery and (ii) absence of any apparent clinical or imaging abnormality . As it is a rather aggressive and costly treatment, it should be restricted exclusively to highly selected patients presenting a high risk of developing PC. A major proportion of the at-risk population has recently been defined by Elias et al. and concerns: (i) patients presenting a few nodules of synchronous PC which are completely resected with the primary tumor, (ii) patients with ovarian metastases, and (iii) patients with a perforated primary tumor (spontaneous or iatrogenic) or accidental intraoperative tumor spillage