We created box plots to visualize extracted physiologicalparameters. We used R (Rstudio 2017) and R package afex[37] to perform a linear mixed effects analysis of theextracted physiological parameters between each lesiongroup and its corresponding visually-normal sites. As a fixedeffect, we entered the lesion pathology type into the model.As random effects, we had intercepts for patients andlesions. Visual inspection of residual plots did not reveal anyobvious deviations from homoscedasticity or normality.P-values were obtained by the Kenward-Roger approximation using R package afex [37].