Before and after study dates, thyroid hormones were almost the same in this study. A wide variety studies shows that glandular cells of the thyroid gland are considered resistant to radiation [18], but there is a possibility that extensive radiation over the permissible dose enhances the aberrant production of thyroid hormone or the generation of neoplasms and cysts [10]. Scientists are conducting research into changes of thyroid hormone levels during radiotherapy from kinds of various cancers to show the incidents of hypothyroidism after cancer radiotherapy [10,19,20] and other scientists do not believe that incidents of hypothyroidism after radiotherapy and also say that hypothyroidism is categorized as a late disturbance of radiation [21]. Thus, patients who have a long interval after radiotherapy are at high risk of hypothyroidism. In addition, our results did not reveal any changes of TSH, T3 and T4 levels before and after radiotherapy. As a result, we can say that one of the most important factors for their changes is the number of months that we follow up patients after radiotherapy. Moreover, Garcia-Serra et al. offered a suggestion that serum TSH levels can be checked every 6 months for the first year [22]. It is well known that primary radiation induces thyroid hormonal changes and may enhance different damages [23]. Also, we can say that thyroid is prone to secondary radiation in breast cancer radiotherapy. Therefore, receiving dose is low.