【药代动力学】盐酸萘替芬：健康人单剂外用1%的盐酸萘替芬乳膏，约有6%

Pharmacokinetics] <br>naftifine hydrochloride: healthy single dose of 1% topical cream naftifine hydrochloride, about 6% of the dose is absorbed, naftifine hydrochloride and its metabolites in the urine and fecal excretion, half-life of about 2 to 3 days. Naftifine hydrochloride through the skin layer has a sufficient concentration to inhibit the growth of dermatophytes. <br>Ketoconazole: normal skin rubbed in Beagle dogs and abraded skin 2% ketoconazole cream, a dose 80mg / day, once every 28 days, the drug was not detected in blood (the minimum detection limit of 2ng / ml). Healthy volunteers topical agent 2% ketoconazole cream in the chest, back and arms, the blood within 72 hours of drug were not detected (the minimum detection limit of 5ng / ml). <br>Pharmacology and toxicology <br>adenosylmethionine human tissues and body fluids is ubiquitous a physiologically active molecule. As the methyl donor (meth rotation effect) and physiological precursor mercapto compounds (e.g., cysteine, taurine, glutathione and coenzyme A, etc.) of the (thio transfer action) involved in important vivo biochemical reactions. In the liver, liver cell membrane fluidity is adjusted by making the plasma membrane phospholipid methylation, but also promote the detoxification process of synthesis by a vulcanized product group transfer reaction. As long as the liver bioavailability adenosylmethionine in the normal range, which will help to prevent the reaction intrahepatic cholestasis.

Pharmacokinedodynamics<br>Cetann hydrochloric acid: Healthy people use 1% of the extra-dose of cesa hydrochloride cream, about 6% of the dose is absorbed, hydrochloric acid fentanyl and its metabolites excreted through urine and feces, half-life is about 2 to 3 days. There is sufficient concentration to inhibit the growth of skin fungi through the epidermis.<br>Ketoconazole: Apply 2% ketoconazole cream on the normal skin and bruised skin of Beagle dog, at a dose of 80 mg/day, for 28 days, and no drugs were detected in the blood (minimum detection limit of 2 ng/ml). Healthy volunteers used 2% ketone conazole cream in the chest, back and arms, and no drugs were detected in the blood within 72 hours (minimum detection limit of 5 ng/ml).<br>Pharmacology<br>Adenosine methionine is a physiologically active molecule common in human tissues and body fluids. It participates in important biochemical reactions in the body as a precursor to methyl donors (transmethyl) and physiological carphesine compounds (e.g. cysteine, taurine, glutathione and coenzyme A, etc.). In the liver, the fluidity of the liver cell membrane is regulated by methylation of the protomembrane phospholipid, and the synthesis of vulcanization products during detoxification can be promoted by the transsulfurization reaction. These reactions help prevent bile siltation in the liver as long as the bioavailability of adenosine methionine in the liver is within the normal range.

[pharmacokinetics]<br>Naftefen hydrochloride: a single dose of 1% naftefen hydrochloride cream is applied to healthy people, about 6% of which is absorbed. Naftefen hydrochloride and its metabolites are excreted through urine and feces, with a half-life of about 2-3 days. Naftopifen hydrochloride has enough concentration to inhibit the growth of dermatophytes.<br>Ketoconazole: Apply 2% ketoconazole cream on the normal skin and abraded skin of beagle dogs at a dose of 80mg / day for 28 days. No drug is detected in the blood (the minimum detection limit is 2ng / ml). A single dose of ketoconazole cream was applied to the chest, back and arm of healthy volunteers. No drug was detected in the blood within 72 hours (the minimum detection limit was 5ng / ml).<br>Pharmacology and Toxicology<br>Adenosylmethionine is a kind of physiologically active molecule widely existing in human tissues and body fluids. It is involved in the important biochemical reactions in vivo as the precursor of methyl donor (transmethylation) and physiological sulfhydryl compounds (such as cysteine, taurine, glutathione and coenzyme A). In the liver, the fluidity of liver cell membrane is regulated by methylation of plasma membrane phospholipid, and the synthesis of sulfurized products can be promoted by trans sulfur reaction. As long as the bioavailability of adenosylmethionine in the liver is within the normal range, these reactions will help to prevent intrahepatic cholestasis.<br>