Therefore, we speculate that antxr1 activates Wnt by interacting with LRP6/ β- Catenin pathway regulation γ Globin expression. Studies have shown that the extracellular domain of LRP6 is sufficient to interact with TEM8.
Therefore, we speculate that ANTXR1 can activate Wnt/β-catenin pathway by interacting with LRP6 to regulate the expression of γ globin. The research shows that the extracellular domain of LRP6 is enough to interact with TEM8.