4. Discussion and general recommendations for the therapeutic strategy to manage the agitation or aggressiveness crisis Faced with an agitation or aggressiveness crisis, the strategy consists first in eliminating any underlying process (e.g. pain, sepsis, metabolic disorders), adapting the environment bysuppressing the constraints and taking away perfusions – Expert opinion. Patient often present with an inversion of the sleep/wake cycle and one important objective is to try to reestablish a normal sleep pattern – Expert opinion. It is essential to reassess the situation and sometimes envision a medical treatment (Fig. 2,inspired by Lombard and Zafonte [3]).Generally, the level of evidence in favor of using medications in the agitation or aggressiveness crisis remains quite low. Based on our review of the literature and expert opinion, the following general recommendations were set: in case of an agitation crisis, using a pharmacological treatment should not be a unique or systematic response. Medical treatments of psychological comorbidities (anxiety, depression, bipolar disorders, sleep disorders, delirium...) must abide by the guidelines for these comorbidities taking into account the individual response of the patient and the brain damage, especially concerning dose adjustment – Expert opinion.Several precautions of use or guidelines for psychotropic agentsafter TBI appear quite consensual: