wellness screening for healthy middle-aged pets and twice yearly screening for senior pets (i.e.,last 25% of predicted lifespan). At each visit,the pet should receive a physical examination and laboratory tests and the owner should be extensively questioned about changes in behavior and health (Epstein et al, 2005). Most of these changes would not be detected during a veterinary visit because they can be intermittent,subtle in onset and only noticeable in other environments.Therefore a senior care program should include use of a screening questionnaire (Table 35-1). (Landsberg and Araujo, 2005; Landsberg et al, 2003; Pfizer Animal Health) and/or allow sufficient time for interactive history taking.If problems are identified,early intervention may improve quality of life and longevity. The reliability and usefulness of brain imaging for detection