由于四氢吡咯环大量存在于生物碱的结构中，而此反应最为成功的应用莫过于合

Since tetrahydropyrrole rings are abundantly present in the structure of alkaloids, the most successful application of this reaction is to synthesize alkaloids with cis-aryl octahydroindole ring as the skeleton structure, such as the Amaryllidaceae, The aza-Cope-Mannich rearrangement reaction has become the cornerstone of the total synthesis of a series of alkaloids, such as the alkaloids belonging to the genus Cypress and logan.

Since tethydrocarbon rings are found in a large number of alkaloid structures, and the most successful application of this reaction is to synthesize alkaloids with a shun-aromatic octahydrocarbon rings as skeleton structures, as shown in the figure below, such as stone garlic, white wood, horse money alkaloids, etc., aza-Cope-Mannich re-discharge reaction has become the cornerstone of a series of alkaloid synthesis.

Because tetrahydropyrrole rings are abundant in alkaloid structures, the most successful application of this reaction is to synthesize alkaloids with CIS aryl octahydroindole ring as the skeleton structure, such as Lycoris, Leucaena and loganin in the figure below. The aza cope Mannich rearrangement reaction is the cornerstone of a series of alkaloid total synthesis.<br>