lipid-modifying agents. This is in

lipid-modifying agents. This is in contrast to recent literatureshowing a significant relation of aortic plaques and calciumwith only the descending aorta.21 22 In conclusion, although wefound differences between the ascending and descending aortain the association between smoking, alcohol consumption andHDL cholesterol, the effect of these cardiovascular risk factorsseems of limited importance in explaining the overall variationin aortic diameter.In addition, we found that blood pressure was associated withthoracic aortic diameters. We found a positive association of thediastolic blood pressure but a negative association of the systolicblood pressure with aortic diameters. Whether hypertension isindeed a risk factor for aortic dilatation is still unknown,23 butour results suggest that high diastolic blood pressure might bemore important in the development of aortic dilatation thanhigh systolic blood pressure. Current guidelines2 advise toreduce blood pressure (both systolic and diastolic). The importanceof high diastolic blood pressure on aortic diameters shouldbe stressed and deserves more attention, also in research.We found diabetes to be negatively associated with both theascending and descending aortic diameters. This phenomenonhas already been shown in the abdominal aorta, where it isdescribed that diabetes is associated with less aortic dilatationof the abdominal aorta.24 25 This might be caused by advancedglycation associated with diabetes which inhibits through intermediatesteps secretion of the matrix metalloproteinases.25 Also,the fibrinolytic pathway, more specifically the plasminogenactivator inhibitor-1, is mentioned as a candidate mechanismfor hyperglycaemic inhibition of abdominal aortic disease.26More research is warranted to elucidate the role of these pathwaysin the development of both thoracic and abdominal aorticaneurysms.Strengths of our study include the population-based settingand the relatively large sample size. By including participantswith hypertension or a history of CVD, we measure the aorticdiameter in the general population and not only in healthypeople. Therefore, the results can be generalised to a largerproportion of the older population.

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结果 (简体中文) 1: [复制]

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调脂药物。这与最近的文献 显示主动脉斑块的显著关系和钙 仅下降aorta.21 22总之，虽然我们 发现，升和降主动脉之间的差异 在吸烟，饮酒和之间的关联 HDL胆固醇时，这些心血管危险因素的效应 在解释总体变化似乎意义有限 主动脉直径。 此外，我们发现血压与相关的 胸主动脉直径。我们发现的正相关 舒张压，但收缩的负相关 血压主动脉的直径。无论是高血压 的确主动脉扩张的危险因素仍是未知数，但23 我们的研究结果表明，高舒张压可能是 在主动脉扩张比发展更重要的 高收缩压。当前guidelines2 奉劝 降低血压（收缩压和舒张压）。重要性 主动脉直径高舒张压应 强调，值得更多的关注，也在研究。 我们发现糖尿病与两者呈负相关 升序和降序主动脉直径。这种现象 已经显示腹主动脉，它在哪里 描述了糖尿病与较少主动脉扩张相关联 的腹部aorta.24 25这可能是由先进而引起的 与糖尿病相关的糖基化，其通过中间抑制 基质metalloproteinases.25步骤分泌此外， 所述纤维溶解途径，更具体地，纤维蛋白溶酶原 激活物抑制剂-1，被提及作为候选人机制 腹主动脉disease.26的高血糖抑制 更多的研究来阐明这些途径的作用， 在这两个胸，腹主动脉的发展 动脉瘤。 我们研究的优势包括：基于人口的设置 和比较大的样本量。通过包括参与者 有高血压或心血管疾病的病史，我们测量主动脉 在总人口中直径不仅在健康 人。因此，该结果可以推广到一个更大的 老年人口比例。

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结果 (简体中文) 2:[复制]

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lipid-modifying agents. This is in contrast to recent literature showing a significant relation of aortic plaques and calcium with only the descending aorta.21 22 In conclusion, although we found differences between the ascending and descending aorta in the association between smoking, alcohol consumption and HDL cholesterol, the effect of these cardiovascular risk factors seems of limited importance in explaining the overall variation in aortic diameter. In addition, we found that blood pressure was associated with thoracic aortic diameters. We found a positive association of the diastolic blood pressure but a negative association of the systolic blood pressure with aortic diameters. Whether hypertension is indeed a risk factor for aortic dilatation is still unknown,23 but our results suggest that high diastolic blood pressure might be more important in the development of aortic dilatation than high systolic blood pressure. Current guidelines2 advise to reduce blood pressure (both systolic and diastolic). The importance of high diastolic blood pressure on aortic diameters should be stressed and deserves more attention, also in research. We found diabetes to be negatively associated with both the ascending and descending aortic diameters. This phenomenon has already been shown in the abdominal aorta, where it is described that diabetes is associated with less aortic dilatation of the abdominal aorta.24 25 This might be caused by advanced glycation associated with diabetes which inhibits through intermediate steps secretion of the matrix metalloproteinases.25 Also, the fibrinolytic pathway, more specifically the plasminogen activator inhibitor-1, is mentioned as a candidate mechanism for hyperglycaemic inhibition of abdominal aortic disease.26 More research is warranted to elucidate the role of these pathways in the development of both thoracic and abdominal aortic aneurysms. Strengths of our study include the population-based setting and the relatively large sample size. By including participants with hypertension or a history of CVD, we measure the aortic diameter in the general population and not only in healthy people. Therefore, the results can be generalised to a larger proportion of the older population.

正在翻译中..

结果 (简体中文) 3:[复制]

复制成功！

脂质修饰剂。这与最近的文献相反 主动脉斑块与钙的关系 只有降主动脉。21 22总之，尽管我们 发现升主动脉和降主动脉之间的差异 吸烟、酗酒和 高密度脂蛋白胆固醇，这些心血管危险因素的影响 似乎在解释整体变化方面的重要性有限 主动脉直径。 此外，我们发现血压与 胸主动脉直径。我们发现 舒张压与收缩压呈负相关 有主动脉直径的血压。高血压是否 确实，主动脉扩张的危险因素还不清楚，但是 我们的结果表明，舒张压高可能是 在主动脉扩张的发展中比 收缩压高。现行指南2 建议 降低血压（收缩压和舒张压）。重要性 高血压对主动脉直径的影响 在研究中也要有更多的压力和关注。 我们发现糖尿病与 升主动脉和降主动脉直径。这种现象 已经显示在腹主动脉 糖尿病与主动脉扩张减少有关 腹主动脉。24 25这可能是由于晚期 糖基化与糖尿病的关系 促进基质金属蛋白酶的分泌， 纤溶途径，尤其是纤溶酶原 激活抑制剂-1，作为候选机制被提及 用于腹主动脉疾病的高血糖抑制。26 需要更多的研究来阐明这些途径的作用 在胸主动脉和腹主动脉的发育过程中 动脉瘤。 我们研究的优势包括以人口为基础的环境 以及相对较大的样本量。包括参与者 如果有高血压或心血管病史，我们会测量主动脉 一般人群的直径，而不仅仅是健康人群的直径 人。因此，结果可以推广到更大的 老年人口比例。

正在翻译中..

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