阿折地平是一种新型二氢吡啶类钙通道阻滞剂，其化学结构与硝苯地平相似，通

Azelnidipine is a new dihydropyridine calcium channel blocker nifedipine and its chemical structure is similar to calcium influx peripheral vascular and coronary vasodilation by suppressing produce hypotensive effect. <br>This design introduces Azelnidipine 30 tons of plant design, 2- (3-nitro-benzylidene) isopropyl acetoacetate (V) and 1- benzhydryl-3-butoxy Ah amidino piperidinol acetate acetate (IV) was dissolved in isopropanol and added sodium methoxide by heating to reflux, cooled, filtered, and dissolved by heating cooling crystallization, azelnidipine pale yellow crystals yield: 98%. <br>This design mainly includes Azelnidipine synthetic process plant design basis, a block diagram of the design process, the process described, the whole process material balance, heat balance, selection and process design calculations, with the process flow diagram of a control point, workshop FIG content design equipment design and floorplan design typical process, a "waste" processing and utilization and the like.

阿折地平是一种新型二氢吡啶类钙通道阻滞剂，其化学结构与硝苯地平相似，通过抑制钙离子内流使外周血管和冠脉血管舒张，产生降血压作用。<br>本设计介绍了年产30吨阿折地平的车间设计，将2-(3-硝基苄叉)乙酰乙酸异丙酯(V)与1-二苯甲基-3-丫丁啶醇脒基醋酸酯醋酸盐(IV)溶于异丙醇中, 并加入甲醇钠，通过加热回流、冷却、过滤、加热溶解冷却结晶，得淡黄色阿折地平结晶，收率:98%。<br>本设计内容主要包括阿折地平合成的车间工艺设计依据，工艺流程框图设计，工艺过程描述，全流程物料衡算，热量衡算，工艺设计选型与计算，带控制点的工艺流程图、车间设计的平面布置图及典型工艺设计的装备图的设计，“三废”处理及其综合利用等内容。

Azerdipine is a new type of dihydropyridine calcium channel blocker. Its chemical structure is similar to that of nifedipine. It can relax the peripheral blood vessels and coronary vessels by inhibiting the internal flow of calcium ions, which has the effect of lowering blood pressure.<br>This design introduces the workshop design of 30 t / a Azelnidipine, dissolving 2 - (3-nitrobenzylidene) isopropyl acetate (V) and 1-diphenylmethyl-3-yabutadinolamidine acetate (IV) in isopropanol, adding sodium carbinol, heating reflux, cooling, filtering, heating dissolution, cooling and crystallization, obtaining light yellow Azelnidipine crystal, yield: 98%.<br>This design mainly includes the workshop process design basis, process flow chart design, process description, material balance calculation of the whole process, heat balance calculation, process design selection and calculation, process flow chart with control points, layout plan of workshop design and equipment drawing design of typical process design, treatment and comprehensive utilization of "three wastes", etc.