The thrombin-induced degradation of

还使用QCM测量了凝血酶诱导的3种不同DCL水凝胶的降解。如图2b所示，当暴露于凝血酶溶液（0.01 PBS中的20 U mL？1）时，这三种凝胶的频率均增加，表明凝胶降解。根据曲线初始上升部分的线性部分，可以估算出水凝胶的平均降解率。45如图S4a（ESI†）所示，降解率随着DCL的降低而增加。造成此结果的主要原因可能是低DCL的水凝胶结构较疏松，孔较大，两者均促进凝血酶扩散。

不同DCL的三个水凝胶的血栓发生降解，当暴露于血栓蛋白溶液（0.01 M PBS中的20 U mL1）时，所有三种凝胶的频率都增加了，表明凝胶降解。根据曲线初始上升部分的线性部分，估计水凝胶的平均降解率。S4a （ESI®），降解率随着 DCL 的减少而增加。这一结果的主要原因是，低DCL水凝胶具有松散的结构和大毛孔，这两种均有助于血栓扩散。

The thrombin-induced degradation of three hydrogels of differentDCL wasalsomeasuredusingaQCM.AsshowninFig.2b,the frequency increased for all three gels when exposed to thrombin solution (20 U mL1 in 0.01 M PBS), indicating gel degradation. Based on the linear part of the initial rising portion of the curves, the average degradation rates of the hydrogels were estimated.45 As shown in Fig. S4a (ESI†), the degradation rate increased as the DCL decreased. The main reason for this result is probably that hydrogels of lower DCL havea looserstructureandlarger pores, both ofwhich facilitate thrombin diffusion.<br>