ResultsElevated levels of PD-1+ TIGIT+ T cells in patients with HBV-HCCTo evaluate the roles of PD-1 and TIGIT expression in the pathogenesis and progression of HBV-HCC, we performed flow cytometric analysis of PD-1 and TIGIT on CD4+ and CD8+ T cells from CHB, HBV-LC, and HBV-HCC patients. Age-matched healthy donors were taken as controls. The percentages of PD-1+ and TIGIT+ cells in the CD4+ T-cell population were apparently elevated in HBV-HCC, compared with healthy donors and CHB or HBV-LC patients (P