Fluorouracil (5-FU), a commonly use

氟尿嘧啶（5-FU）是一种常用的抗癌药，具有强大的心脏毒性，其由血管内皮损伤和血管痉挛介导。在这里，我们报道了一名患者出现房颤（AF），这很可能是由5-FU介导的血管痉挛引起的。一名69岁男子出现吞咽困难，并被诊断患有晚期食道癌。包括5-FU在内的联合化疗期间观察到频繁的房颤发作。AF对二吡amide酰胺难治，但对抗心绞痛药（尼可地尔和硝酸甘油透皮贴剂）敏感。在化疗期间进行的冠状动脉造影显示右冠状动脉（RCA）出现中度狭窄。通过使用乙酰胆碱的激发试验，在RCA的心房分支近端出现严重痉挛。我们的病例表明5-FU在RCA中易发生血管痉挛，随后的心房缺血可能导致房颤。。<BR><BR><BR>关键词

氟尿酸（5-FU），一种常用的抗癌剂，具有强大的心毒性，由血管内皮损伤和血管膜炎中调节。在这里，我们报告一个病人证明心房颤动（AF），这很可能是由5-FU调解的血管膜引起的。一名69岁男子患有吞咽困难，被诊断为晚期食道癌。在包括5-FU）的组合化疗期间观察到心房颤动（AF）的频繁性氧质。AF耐火性为去异酰胺，但对抗阳毒剂（尼兰迪尔和硝化甘油转皮贴片）敏感。在化疗期间进行的冠状动脉造影显示右冠状动脉（RCA）中度狭窄。RCA中心房分支的近部严重痉挛是由使用乙酰胆碱的挑衅试验引起的。我们的案例表明，RCA 中的 5-FU 易性血管膜和随后的心房缺血可能导致 AF。.<BR><BR>关键 字

Fluorouracil (5-FU), a commonly used anticancer agent, has potent cardiotoxicity that is mediated by vascular endothelial injury and vasospasm. Here, we report a patient demonstrating atrial fibrillation (AF), which was most likely induced by vasospasm mediated by 5-FU. A 69-year-old man presented with dysphagia and was diagnosed with advanced esophageal cancer. Frequent paroxysms of atrial fibrillation (AF) were observed during combination chemotherapy including 5-FU. AF was refractory to disopyramide, but was sensitive to antianginal agents (nicorandil and nitroglycerin transdermal patch). Coronary angiography performed within the chemotherapeutic period demonstrated moderate stenosis in the right coronary artery (RCA). Severe spasm at the proximal portion of the atrial branch in RCA was induced by provocation test using acetylcholine. Our case indicated that 5-FU predisposed vasospasm in RCA and the subsequent atrial ischemia may lead to AF. . Keywords<BR>