[0108] The microbioreactor 100 includes an actuator system that is configured to move the container assembly 200 in an orbital fashion. Continuous shaking improves the aeration of the wells 61 and prevents sedimentation inside the wells. Thus, interrupting the shaking while pipetting into a well or out of a well is not desirable. In order to prevent the apertures 15, 6 of the first and second resilient layers 13, 4 from wearing out, the pipette tip 71 must hit the middle of the apertures 15, 6 to avoid harming the flanks of the apertures 15, 6.