Study design: Spinal cord injury (S

Study design: Spinal cord injury (SCI)patients with pressure sores were studied before andafter surgical intervention for ulcer healing and compared with matched SCI patients withoutsores and with patients with pressure sores and other diseases.Objective: To analyse the relationship between pressure sores and anaemia and serum proteinalteration in SCI patients. To study the pathogenesis of these alterations and suggestappropriate therapy.Setting: Spinal cord unit in Rome, Italy.Subjects: A total of 13 SCI patients with pressure sores, 13 comparable patients withoutpressure sores and four patients with other diseases and pressure sores.Main measures: Haematochemical parameters.Results: Patients with pressure sore showed significant decreased red cells, decreasedhaemoglobin and haematocrit, increased white cells and ferritin and decreased transferrinand transferrin saturation; total hypoproteinemia and hypoalbuminemia with increased Alfa-1and gamma globulins increased erythrocyte sedimentation rate and C-reactive protein were alsopresent. The alterations returned to normal after surgical intervention for pressure sore healing.Conclusions: Patients with pressure sores suffer from anaemia and serum protein alterationthat fells within the range of metabolic alteration of chronic disorders and neoplastic diseases.The alterations depend on a decreased utilisation of iron stores in the reticuloendothelial systemand on inhibition of the hepatic synthesis of albumin. With regard to treatment, iron treatmentshould be avoided because of the risk of haemochromatosis.

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结果 (简体中文) 1: [复制]

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研究设计：对有压疮的脊髓损伤（SCI）患者 在手术干预前后进行溃疡愈合的研究，并将其与匹配的无 溃疡的SCI患者以及有压疮和其他疾病的患者进行比较。 目的：分析 脊髓损伤患者的压疮与贫血及血清蛋白改变的关系。要研究这些改变的发病机理并建议 适当的治疗方法。 地点：意大利罗马的脊髓装置。 受试者：共有13例SCI压疮患者，13例可比的无 压疮患者和4例其他疾病和压疮患者。 主要措施：血液化学参数。 结果：褥疮患者的红细胞明显减少， 血红蛋白和血细胞比容减少，白细胞和铁蛋白增加 ，转铁蛋白和转铁蛋白饱和度降低；还存在总的低蛋白血症和低白蛋白血症以及Alfa-1 和γ球蛋白增加，红细胞沉降率和C反应蛋白增加 。手术治疗压疮后，这些改变恢复正常。 结论：压疮患者患有贫血和血清蛋白改变 ，其属于慢性疾病和赘生性疾病的代谢改变范围。 这种改变取决于网状内皮系统中铁存储的减少利用 并且抑制白蛋白的肝合成。关于治疗， 由于有血色素沉着病的风险，应避免铁治疗。

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结果 (简体中文) 2:[复制]

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Study design: Spinal cord injury (SCI)patients with pressure sores were studied before and after surgical intervention for ulcer healing and compared with matched SCI patients without sores and with patients with pressure sores and other diseases. Objective: To analyse the relationship between pressure sores and anaemia and serum protein alteration in SCI patients. To study the pathogenesis of these alterations and suggest appropriate therapy. Setting: Spinal cord unit in Rome, Italy. Subjects: A total of 13 SCI patients with pressure sores, 13 comparable patients without pressure sores and four patients with other diseases and pressure sores. Main measures: Haematochemical parameters. Results: Patients with pressure sore showed significant decreased red cells, decreased haemoglobin and haematocrit, increased white cells and ferritin and decreased transferrin and transferrin saturation; total hypoproteinemia and hypoalbuminemia with increased Alfa-1 and gamma globulins increased erythrocyte sedimentation rate and C-reactive protein were also present. The alterations returned to normal after surgical intervention for pressure sore healing. Conclusions: Patients with pressure sores suffer from anaemia and serum protein alteration that fells within the range of metabolic alteration of chronic disorders and neoplastic diseases. The alterations depend on a decreased utilisation of iron stores in the reticuloendothelial system and on inhibition of the hepatic synthesis of albumin. With regard to treatment, iron treatment should be avoided because of the risk of haemochromatosis.

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结果 (简体中文) 3:[复制]

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研究设计：对有压疮的脊髓损伤（SCI）患者进行研究 术后溃疡愈合与对照组比较 有压疮和其他疾病的病人。 目的：分析压疮与贫血及血清蛋白的关系 脊髓损伤患者的改变。研究这些改变的发病机制并提出建议 适当的治疗。 单位：意大利罗马脊髓单位。 受试者：共有13名脊髓损伤患者有压疮，13名无压疮的可比患者 压疮及其他疾病压疮4例。 主要指标：血液化学指标。 结果：压疮患者红细胞明显减少，红细胞减少 血红蛋白和红细胞压积，增加白细胞和铁蛋白，降低转铁蛋白 和转铁蛋白饱和；总低蛋白血症和低蛋白血症，Alfa-1增加 丙种球蛋白增加血沉，C反应蛋白也增加 现在。压疮术后恢复正常。 结论：压疮患者贫血及血清蛋白改变 在慢性疾病和肿瘤疾病的代谢改变范围内。 这种改变依赖于网状内皮系统中铁储备的利用率降低 抑制肝脏合成白蛋白。关于处理，铁处理 应该避免，因为有血色素沉着的危险。

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