【注意事项】1、 过敏反应本品为采用基因工程方法制备的多组分药物，包含

[Note] <br>1, allergic <br>product multicomponent pharmaceutical preparation by genetic engineering method, comprising a plurality of components, the main components of 4 "- isovaleryl spiramycin III, II, I, followed by 4" - Acetylspiramycin II and III, and 4 '- butyryl and 4 "- isobutyryl spiramycin III, II two pairs of isomers, and 4' - (3-methyl-2-butene acyl) spiramycin II and 4 '- propionyl spiramycin III, II. This product is macrolides, it is possible to macrolides allergy allergy also present. Therefore, macrolide drug allergy FDA ban. This product is used in the process should be closely observed, such as found in drug fever, rash, hives, edema, eosinophilia symptoms of allergic reaction, and should be discontinued immediately reported to the doctor, timely appropriate treatment. <br>This product has no existing clinical trials a severe allergic reaction, such as angioedema and including anaphylactic shock reactions (rarely fatal), and comprising a Stevens- Johnson syndrome and toxic epidermal necrolysis (rarely fatal ), including skin reactions, but should be concerned about. <br>Reported in the literature, such as severe allergic reactions azithromycin macrolide drugs can cause recurrent, it takes longer observation and treatment. <br>Doctors should recognize the symptoms of a severe allergic reaction may occur again after stopping symptomatic treatment. <br>2, liver toxicity <br>This product is mainly metabolized through the liver, jaundice and abnormal liver function should be used with caution in patients with severe liver disease should not be used.

Notes<br>1, allergic reaction This product is a multi-component drug prepared by genetic engineering methods, containing a variety of components, the main component sylph isolyl iliac III, II, I, followed by 4" - acetyl helicomycin III and II, and 4" - butyl and 4" - isobutyl helicocin III, II two pairs of isomers, and 4" - (3- Methyl-2-butyl) helicomycin II and 4"-acrylhesicomycin III, II. This product belongs to the large ring ester drug, the large ring ester drug allergy may also be allergic to this product. Therefore, this product is banned for those allergic to large ring esters.<br>This product should be closely observed in the process of use, such as the discovery of drug fever, rash, urticaria, edema, acidophiles and other symptoms of allergic reactions, should immediately stop the drug and report to the doctor, timely use of appropriate treatment measures.<br>Existing clinical trials of this product have not seen severe allergic reactions, including vascular edema and anaphylactic shock reactions (rarely fatal), as well as skin reactions including Stevens-Johnson syndrome and toxic epidermis necrosis (rare lysate) (rarely fatal), but should be noted.<br>Literature reported that azithromycin and other large cyclosteric esters caused by severe allergic reactions can be repeated, requires a longer period of observation and treatment.<br>Doctors should be aware that symptoms of severe allergic reactions may reappear after discontinuation of treatment.<br>2, hepatotoxicity This product is mainly through liver metabolism, liver function abnormalities and jaundice patients should be used with caution, serious liver disease patients should not use.

[Notes]<br>1. Allergic reaction<br>This product is a multi-component drug prepared by genetic engineering. It contains many components. Its main components are 4"- isovaleric spiramycin III, II, I, followed by 4" - Acetylspiramycin III and II, and two pairs of isomers of 4"- butyryl and 4" - isobutyryl spiramycin III, II, and 4"- (3-methyl-2-butenyl) spiramycin II and 4" - propionyl spiramycin III, II. This product belongs to macrolide drugs. Those who are allergic to macrolide drugs may also be allergic to this product. Therefore, this product is forbidden for those who are allergic to macrolides. Close observation should be made during the use of this product. If symptoms of allergic reactions such as drug fever, rash, urticaria, edema and eosinophilia are found, the drug should be stopped immediately and reported to the doctor, and appropriate treatment measures should be taken in time.<br>No serious allergic reactions were found in the current clinical trials, including vascular edema and anaphylactic shock (rare fatality), skin reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis (rare fatality), etc. However, attention should be paid.<br>It has been reported in the literature that severe allergic reactions caused by azithromycin and macrolides can occur repeatedly and require long-term observation and treatment.<br>Doctors should recognize that severe allergic symptoms may reappear after symptomatic cessation of treatment.<br>2. Hepatotoxicity<br>This product is mainly through liver metabolism, liver dysfunction and jaundice patients should be cautious to use, severe liver disease patients should not use.<br>