Implantation models are generally v

植入模型通常在破译肿瘤<br>血管生成的机制以及给定的血管生成刺激剂或抑制剂，受体或<br>调节细胞内因子的作用中非常有用。唯一的缺点是<br>异种移植中缺乏适应性免疫系统，因此必须谨慎解释数据。另一个<br>挑战是植入部位。通常，最好原位植入肿瘤细胞，<br>因为在这种情况下存在正确的宿主组织。另一个挑战是是否<br>植入细胞悬液或球体。球体在许多情况下似乎更适合，因为<br>它们已经采用了3D组织结构，并保留了一些遗传程序<br>在3D组织中遇到的问题。例如<br>在<br>成胶质细胞瘤中遇到的抗血管生成疗法可以诱导共选择生长。

Implantation models are generally very useful in deciphering mechanisms of the tumor <br>angiogenesis and the role of given angiogenesis stimulator or inhibitor, receptors or <br>modulating intracellular factors. The only drawback is that the adaptive immune system in <br>xenotransplantations is absent and thus the data must be interpreted with care. The other <br>challenge is the implantation site. Usually, it is better to orthotopically implant tumor cells <br>since the correct host tissue is present in this case. Another challenge is whether or not to <br>implant cell suspensions or spheroids. Spheroids seem in many cases better suited because <br>they already adopt a 3D tissue configuration which preserves some of their genetic program <br>that is encountered in a 3D tissue.<br>Co-optive growth may be induced by anti-angiogenic therapy as it is encountered in <br>glioblastoma for instance.

植入模型通常在破译肿瘤机制方面非常有用<br>血管生成和给定的血管生成刺激物或抑制剂、受体或<br>调节细胞内因子。唯一的缺点是适应性免疫系统<br>没有异种移植，因此必须小心解释数据。其他的<br>挑战在于植入部位。通常，原位移植肿瘤细胞比较好<br>因为在这种情况下存在正确的宿主组织。另一个挑战是是否<br>植入细胞悬液或球体。在许多情况下，球体似乎更合适，因为<br>他们已经采用了一种三维组织结构来保存他们的一些遗传程序<br>在三维组织中遇到的。<br>协同生长可能是由抗血管生成治疗诱导的，因为它是在<br>例如胶质母细胞瘤。