Abbreviations: ACS, acute coronary syndrome; CANVAS, CANagliflozin CardioVascular Assessment Study; CHD, coronary heart disease; CKD, chronic kidney disease ≥stage 3; CI, confidence interval; CV, cardiovascular; CVD, cerebrovascular disease; DPP‐4, dipeptidyl peptidase 4; ELIXA, Evaluation of Cardiovascular Outcomes in Patients with Type 2 Diabetes After Acute Coronary Syndrome During Treatment with AVE0010 (Lixisenatide); EMPA‐REG, Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients; EXAMINE, Examination of cardiovascular outcomes: EXSCEL; Exenatide Study of Cardiovascular Event Lowering; GLP‐1RA, glucagon‐like peptide 1 receptor agonist; HbA1c, glycated haemoglobin; HF, chronic heart failure ‐ NYHA class II or III; HR, hazard ratio; LEADER, Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results; MACE, major adverse cardiac event; MDI, multiple daily injections; MI, myocardial infarction; PVD, peripheral vascular disease; SAVOR, Saxagliptin Assessment of Vascular Outcomes Recorded in patients with diabetes mellitus; SGLT2, sodium‐glucose co‐transporter‐2; SUSTAIN, Trial to evaluate cardiovascular and other long‐term outcomes with Semaglutide in subjects with type 2 diabetes; TECOS, Trial Evaluating Cardiovascular Outcomes with Sitagliptin.a CV disease in LEADER and SUSTAIN‐6 included CHD, CVD, PVD and HF.