Ginkgolide B, one of the important components of Ginkgo biloba exts., 的简体中文翻译

Ginkgolide B, one of the important

Ginkgolide B, one of the important components of Ginkgo biloba exts., has been revealed to exhibit great potential intherapy of cerebrovascular diseases. However the lack of permeability greatly limited it from further clin. application.Based on the prediction model for blood brain barrier (BBB) permeation, herein a potential brain-targeting analogginkgolide B cinnamate (GBC) was successfully synthesized and characterized. After i.v. administration of GBC or GB,liq. chromatog. tandem mass spectrometry (LC-MS/MS) was conducted to det. the analog in rat plasma and brain. Theresults showed that GBC had a significant increase in BBB permeability. A significant 1.61-times increase in half-life wasobsd. for GBC and the drug targeting index (DTI) value was calcd. to be 9.91. The expt. results matched well with thepredicted one, which revealed that BBB permeability prediction model combined with in vivo study could be used as aquick, feasible and efficient tool for brain-targeting drug design
0/5000
源语言: -
目标语言: -
结果 (简体中文) 1: [复制]
复制成功!
银杏内酯B是银杏叶提取物的重要成分之一,已显示出在<br>治疗脑血管疾病方面具有巨大潜力。然而,缺乏渗透性极大地限制了它的进一步发展。应用。<br>基于血脑屏障(BBB)渗透的预测模型,本文<br>成功合成并表征了潜在的靶向脑的类似物银杏内酯B肉桂酸酯(GBC)。对GBC或GB进行静脉注射后,请立即加液<br>。色谱 进行串联质谱分析(LC-MS / MS)。大鼠血浆和脑中的类似物。该<br>结果表明,GBC曾在BBB通透性增加显著。半衰期显着增加1.61倍<br>痴迷。的GBC值,并计算出药物靶向指数(DTI)值。是9.91。该expt。结果与<br>预测的结果非常吻合,表明BBB渗透性预测模型与体内研究相结合可作为一种<br>快速,可行,有效的脑靶向药物设计工具
正在翻译中..
结果 (简体中文) 2:[复制]
复制成功!
银杏B是银杏叶分机的重要组成部分之一,已显示出巨大的潜力。<br>脑血管疾病的治疗。然而,缺乏渗透性极大地限制了它从进一步的clin。应用。<br>基于血脑屏障(BBB)渗透的预测模型,本文存在一种潜在的大脑靶向模拟<br>金基多利德B辛纳马特(GBC)被成功合成和特征。在 I.v. 管理 GB 或 GB 之后,<br>利克. 色度。串联质谱法(LC-MS/MS)对大鼠血浆和大脑中的模拟进行调光。的<br>结果表明,GBC的BBB渗透率显著增加。半生寿命显著增加1.61倍<br>奥布德。对于 GBC 和药物靶向指数 (DTI) 值被计算。是 9.91 。expt. 结果与<br>预测之一,它揭示了BBB渗透性预测模型结合体内研究可以用作<br>快速、可行、高效的脑靶药物设计工具
正在翻译中..
结果 (简体中文) 3:[复制]
复制成功!
Ginkgolide B, one of the important components of Ginkgo biloba exts., has been revealed to exhibit great potential intherapy of cerebrovascular diseases. However the lack of permeability greatly limited it from further clin. application.Based on the prediction model for blood brain barrier (BBB) permeation, herein a potential brain-targeting analogginkgolide B cinnamate (GBC) was successfully synthesized and characterized. After i.v. administration of GBC or GB,liq. chromatog. tandem mass spectrometry (LC-MS/MS) was conducted to det. the analog in rat plasma and brain. Theresults showed that GBC had a significant increase in BBB permeability. A significant 1.61-times increase in half-life wasobsd. for GBC and the drug targeting index (DTI) value was calcd. to be 9.91. The expt. results matched well with thepredicted one, which revealed that BBB permeability prediction model combined with in vivo study could be used as aquick, feasible and efficient tool for brain-targeting drug design<br>
正在翻译中..
 
其它语言
本翻译工具支持: 世界语, 丹麦语, 乌克兰语, 乌兹别克语, 乌尔都语, 亚美尼亚语, 伊博语, 俄语, 保加利亚语, 信德语, 修纳语, 僧伽罗语, 克林贡语, 克罗地亚语, 冰岛语, 加利西亚语, 加泰罗尼亚语, 匈牙利语, 南非祖鲁语, 南非科萨语, 卡纳达语, 卢旺达语, 卢森堡语, 印地语, 印尼巽他语, 印尼爪哇语, 印尼语, 古吉拉特语, 吉尔吉斯语, 哈萨克语, 土库曼语, 土耳其语, 塔吉克语, 塞尔维亚语, 塞索托语, 夏威夷语, 奥利亚语, 威尔士语, 孟加拉语, 宿务语, 尼泊尔语, 巴斯克语, 布尔语(南非荷兰语), 希伯来语, 希腊语, 库尔德语, 弗里西语, 德语, 意大利语, 意第绪语, 拉丁语, 拉脱维亚语, 挪威语, 捷克语, 斯洛伐克语, 斯洛文尼亚语, 斯瓦希里语, 旁遮普语, 日语, 普什图语, 格鲁吉亚语, 毛利语, 法语, 波兰语, 波斯尼亚语, 波斯语, 泰卢固语, 泰米尔语, 泰语, 海地克里奥尔语, 爱尔兰语, 爱沙尼亚语, 瑞典语, 白俄罗斯语, 科西嘉语, 立陶宛语, 简体中文, 索马里语, 繁体中文, 约鲁巴语, 维吾尔语, 缅甸语, 罗马尼亚语, 老挝语, 自动识别, 芬兰语, 苏格兰盖尔语, 苗语, 英语, 荷兰语, 菲律宾语, 萨摩亚语, 葡萄牙语, 蒙古语, 西班牙语, 豪萨语, 越南语, 阿塞拜疆语, 阿姆哈拉语, 阿尔巴尼亚语, 阿拉伯语, 鞑靼语, 韩语, 马其顿语, 马尔加什语, 马拉地语, 马拉雅拉姆语, 马来语, 马耳他语, 高棉语, 齐切瓦语, 等语言的翻译.

Copyright ©2024 I Love Translation. All reserved.

E-mail: