The inhibition of TYLCV transmission by flupyradifurone was compared to that by thiamethoxam, a neonicotinoidinsecticide reported to inhibit virus transmission. The experiment was performed under high virus pressure conditions (10viruliferous insects per plant for 48 h) using a fully characterized field strain of B. tabaci. The insecticides were foliarly appliedat recommended label rates under greenhouse conditions. Flupyradifurone suppressed virus transmission by 85% while levelsof suppression after thiamethoxam treatments were just 25% and significantly lower. In untreated control plots, 100% of plantswere infected by TYLCV. The observed difference in the potential to suppress virus transmission is linked to a strong knockdowneffect as well as prolonged feeding inhibition in flupyradifurone treatments.