At present, the drugs oleanolic aci

At present, the drugs oleanolic acid oleanolic acid tablets, two to pills, capsules Compound Ligustrum lucidum, Chen righting oral liquid, but because of oleanolic acid having strongly hydrophobic, low bioavailability tablet , Yanyao Dong experiments performed cyclodextrin inclusion oleanolic acid, Qi acid can result in increased solubility 12 times, dissolution rate of the product increased ticket 6 times, and between Qi acid and β-cyclodextrin molecules other physical external action, generates no chemical bond, the manufacturing process nor homogeneous acid decomposition reaction, and therefore the bioavailability of oleanolic acid greatly improved, Further, according to the theory Jiangzhao Hui and other prodrugs, oleanolic acid the structures modification, monoesters formed with dicarboxylic acids Cs-OH and then transformed into the disodium salt, making it water soluble disodium salt of a prodrug, oleanolic acid has been synthesized disodium succinate, oleanolic acid disodium maleic acid monoester, cyclohexane oleanolic acid monoester disodium ortho, oleanolic acid monoester disodium phthalate, and preliminary pharmacological experiment results indicate that these protective effect of sodium on experimental liver injury are different than oleanolic acid Improvement in the level, and no oleanolic acid at high doses can aggravate liver damage and side effects is also possible to change from oleanolic acid pharmaceutical dosage forms to improve the bioavailability of oleanolic acid drugs increase efficacy.