3.7. Fucoxanthin Reduced Collagen and COX-2 Expression in the LungsLung collagen accumulation was indicated by Masson’s trichrome stain. Fucoxan- thin decreased collagen expression in the lung tissues from asthmatic mice (Figure 7E,F). Moreover, fucoxanthin significantly decreased the gene expression of COX-2 in the lungs of OVA-sensitized mice (Figure 8A). Subsequently, immunohistochemical staining demon- strated that fucoxanthin could decrease COX-2 expression in the lung tissue compared to the OVA control group (Figure 8B).