All programs(including Macros and a

All programs(including Macros and analysis datasets)producing the tables, listings and statistical output along with associated logs should be given to the sponsor when the tables, listings, figures and statistical analysis has been finalised.Appendix 1 The Boston Bowel Preparation Scale(BBPS)Collected for right(RC), transverse(TC)and left colon(LC).Score per segmentunprepared colon segment with mucosa not seen due to solid stool that cannot be clearedportion of mucosa of the colon segment seen, but other areas of the colon segment not well seen due to staining, residual stool and/or opaque liquid.minor amount of residual staining, small fragments of stool and/or opaque liquid, but mucosa of colon segment seen well.entire mucosa of colon segment seen well with no residual staining, small fragments of stool and/or opaque liquidQuality cleansing definitionPresence of faeces and soiled fluid:investigation could not be reliably performedPresence of faecal material and of unclear fluid, with negative effect on the reliability of the investigationBrown liquid no solid faecal material, presence of unclear residual fluid that could be aspirated - no effect on the reliability of the investigationAbsence of solid faecal material, presence of clear residual fluidNo faecal material, no residual fluid, empty colonHow easy or difficult was it to consume the study drug?Were you able to consume the entire preparation as instructed?Please describe your overall experience of the study preparation:Would you ask your doctor for this preparation again if you needed another colonoscopy in the future?Would you refuse the same preparation again if it were to be prescribed to you in the future?Appendix 4 Wang Scale1=lack of any adverse effect2=AE unrelated to preparation(either with BLI800 or Fortrans®)3=AE possibly related to the preparation without interrupting colonoscopy4=AE related to the preparation and leading to colonoscopy interruptionThe table below shows the five stages of chronic kidney disease(CKD)and glomerular filtration rate(GFR)for each stage:Stage 1 With normal or high GFRNormal kidney function but urine findings or structural abnormalities or genetic trait point to kidney diseaseStage 2 Mild CKDMildly reduced kidney function, and other findings(as for stage 1)point to kidney diseaseStage 3 Moderate CKDStage 4 Severe CKDStage 5 End-stage CKDEstablished kidney failure, kidney dialysis or transplant may be neededAppendix 6 Child-Pugh Classification of Severity of Liver DiseaseChild-Pugh Classification of Severity of Liver Disease:Modified Child-Pugh classification of severity of liver disease according to the degree of ascites, the plasma concentrations of bilirubin and albumin, the prothrombin time, and the degree of encephalopathy.Points assigned*Seconds over controlA total score of 5-6 is considered grade A(well-compensated disease); 7-9 is grade B(significant functional compromise); and 10-15 is grade C(decompensated disease).