Because of a high amount of CO in syngas and poor heat transfer in a fixed-bed reactor, the commercial production for SNG from syngas involves two to four fixed-bed methanation reactors, connected in a series for the cooling or recycling of feed gas to control the heat of the reaction [5,8]. Slurry-bed reactors are ideal reactors for highly exothermic syngas conversion, where catalysts are suspended in an inert liquid medium, which can provide an isothermal reaction temperature because of the good heat removal capability [9,10]. More importantly, because of the low and uniform reaction temperature in a slurry-bed reactor, the carbon deposition and catalyst sintering can be inhibited [11,12]. Therefore, the methanation of CO for SNG production in a slurry bed reactor is a potential process for syngas use.