Unfortunately, neither of them has been demonstrated asa room temperature intrinsic magnetic semiconductor so far.Due to small feasibilities of application, the development ofmagnetic semiconductors slowed down. In recent years, publications on this subject declined rapidly, as shown in Fig. 1.When a scientific gold-rush excitement passed, it is a goodtime to think calmly about the ways for seeking room temperature magnetic semiconductors. Here, we would like to quotefrom Churchill: “This is not the end. It is not even the beginning of the end. But it is, perhaps, the end of the beginning.” Indeed, this is not the first time that the study on magnetic semiconductors sank into a low valley. The question is still open,and a lot of rooms remain for people to exploit. In this review,we will start with a simple historical review to draw inspirations from the past. Then we discuss recent experimental progresses to pursue strong s, p–d interaction to realize room temperature magnetic semiconductors, which are achieved by introducing a very high concentration of magnetic atoms bymeans of low-temperature nonequilibrium growth.